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However, our study has several limitations

4.1.2 Impact of pyruvate kinase and lactate on macrophage phenotype Pyruvate kinase is a key enzyme in the glycolysis pathway: it catalyzes the dephosphorylation of phosphoenolpyruvate into pyruvate and is responsible for the production of ATP during glycolysis

The immunomodulatory influence of probiotics is further attributed to their direct engagement with a range of immune cells, including IECs, DCs, lymphocytes, and monocytes/macrophages (216)