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Without early treatment, it is usually fatal

[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Wu KL, Chaikomin R, Doran S, Jones KL, Horowitz M, Rayner CK

Oral administration is possible in preclinical research

Dimethyl fumarate induces necroptosis in colon cancer cells and the mechanism involves GSH depletion, an increase in ROS and activation of MAPKs-mediated signalling [1]