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Applying ice to the affected area can ease pain and swelling

Even with b12 deficiency, this pathway continues functioning at reduced efficiency rather than stopping completely

PMID: Summary Keywords adenosine, CD38, daratumumab, immunosuppression, immunotherapy, inosine, isatuximab, multiple myeloma Citation Horenstein AL, Frerichs KA, Faini AC, van de Donk NWCJ and Malavasi F (2026) Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective

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The combination addresses both structural protein production and the blood vessel formation necessary to support new tissue