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The landmark 2017 mouse study The foundational research, published in The Journal of Investigative Dermatology by Lee et al., demonstrated several key findings

In schizophrenia, immune activation upregulates pro-inflammatory cytokines (e.g., IFN-, IL-1, TNF-), which activate indoleamine 2,3-dioxygenase (IDO) via both IFN- receptor (IFN-R)-dependent and independent pathways (e.g., synergistic action of TLR4, IL-1R, TNF-R) (215)

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doi: 10.1016/j.cell.2017.09.021 37 TangW.XiaoY.LiG.ZhengX.YinY.WangL.et al

Godwin P, Baird AM, Heavey S, Barr MP, OByrne KJ, et al

This suggests, at least, a potential in the maintenance of the remission state and the prevention of disease flares in IBD patients