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Funding This article was supported by research grants from the National Natural Science Foundation of China (82271069, 82371040, 82122017, 81870642, 81970780, 81470613 and 81670835), Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission (23Y11909800), Outstanding Youth Medical Talents of Shanghai Rising Stars of Medical Talents Youth Development Program, Shanghai Municipal Health Commission Project (2024ZZ1025 and 20244Z0015)

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FIGURE 3 Hyperammonemia with ammonium levels higher than 400500 mol/L increases the risk of irreversible brain damage from five to tenfold

Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives

When the liver function is normal, the simple increase of blood ammonia can reduce the activity of antioxidant enzymes in the cerebral cortex and cerebellum of rats, and induce oxidative stress injury 38

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