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doi: 10.1016/j.psyneuen.2007.03.008 265 KamadaYKisoSYoshidaYChataniNKizuTHamanoMet al

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Steroids, diphenhydramine and bronchodilators can help resolve the anaphylactoid reactions and should be given so that NAC therapy can be continued under close monitoring

Western blotting and RT-PCR demonstrated increased levels of CHOP and ATF6 compared to control, and although this study does not disclose whether psoralen induced additional pathways of DILI (cholestatic, mitochondrial etc.), it indicates that ER stress may be one of the mechanisms involved in psoralen-DILI

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Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy