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Beside pancreas and gut, liver as component of the gastrointestinal tract has also been reported to be affected in cancer cachexia as described in the following section

318 : 639 Farlow MR, Lahiri DK, Poirier J, Davignon J, Schneider L, Hui SL

doi:10.1111/j.1749-6632.2010.05906.x

On one hand, AMPK blocks NF- B nuclear translocation and reduces the transcription and release of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-) and interleukin-6 (IL-6) by enhancing the stability of inhibitor of nuclear factor B alpha (I B ) (Wang et al., 2024a)

These iron ions can exacerbate oxidative stress by catalyzing Fenton and Haber-Weiss reactions, leading to the production of ROS and reactive nitrogen species, which subsequently cause damage to brain cells (Fila et al., 2024)