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ROS produced by erythroid NADPH contributes to the exacerbation of erythroid dysfunction by exacerbating cell stiffness resulting in the increase of hemolysis [142]

As per the mechanism by which cisplatin initializes apoptosis, the main cellular events include an increase in the expression of Bax, the depolarization of mitochondrial membrane, the release of mitochondrial cytochrome c, and the activation of caspase-3