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doi: 10.1016/j.foodchem.2023.138214 229 WangB.SuX.WangT.YangT.XuC.LinZ.et al

J.Murillo-CabezasF.Carrillo-VicoA

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Overproduction of ROS and low levels or deactivation of antioxidant machinery causes increased oxidative stress in cancer cells

NLRP3 inflammasome activation triggers Caspase-1-mediated mitochondrial damage, characterized by increased mtROS production, mitochondrial swelling, and fragmentation, while also inhibiting mitophagy and amplifying mitochondrial damage [11]