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tb -infected mice were treated with 16 mg/kg rifampicin

FIGURE 2 3.1 Mitochondrial metabolism and bioenergetics in gluco- and lipotoxicity Dysregulated mitochondrial bioenergetics, metabolism, and OXPHOS are frequently observed in models of T2D

The decrease in creatinine probably reflects the decreased lean mass, which is the major source of the creatinine precursor, creatine

P =0.009)

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In addition, accessory proteins such as COQ4, COQ8A/B, COQ9 and COQ10A/B are believed to facilitate enzyme complex assembly, substrate channeling or stabilization of the biosynthetic complex (commonly referred to as the CoQ synthome) but their precise molecular functions are still under investigation