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Consequently, failure to convert RanGTP to RanGDP, for example, due to RanGAP depletion, is predicted to result in an accumulation of RanGTP in the cytoplasm and a shift in the ratio of nuclear to cytoplasmic total Ran protein [38]

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Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting. Clinical practice guidelines British Columbia Medical Services Commission (MSC)

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