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Additionally, HIF-1 increases ceruloplasmin, which promotes the oxidation of Fe 2+ to Fe 3+ , facilitating the efflux of iron from cells (Yang et al., 2025)

In more complex or persistent cases, specialists may explore options like steroids, IVIG (intravenous immunoglobulin), or in rare instances, therapeutic plasma exchange (6)

Rachele explains, If you have some kind of lowgrade inflammation or youre injured or youre recovering from a surgery, you can increase the amount of Glutathione in circulation to make sure that youre protected from all of the reactive oxygen species that might be doing damage. 3