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For example, brain derived neurotrophic factor (BDNF) and TNF protect neurons against excitotoxicity through activation of the transcription factor NF-kB, which induces the expression of antioxidant enzymes such as Mn-SOD and the anti-apoptotic proteins, Bcl-2 and inhibitor of apoptosis proteins IAPs [123,124]

Supplementary Table 2 (download XLSX CRISPR screen dataset

Firstly, taurine exerts great anti-oxidant activity by preventing calcium overload during reperfusion (166168) and by protecting the myocardium from LPO products (169)

Therefore, we hypothesize that L-arginine metabolism is part of the E

Comp Biochem Physiol 130C:289303 Rossi R, Dalle-Donne I, Milzani A, Giustarini D (2006) Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress

Melanocytotoxic chemicals and their toxic mechanisms