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D2 has only ORD activity, exhibiting low Km and Vmax values, and a slight preference for T4 over rT3 as the substrate

10.1016/S0140-6736(18)30474-4 438

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Their implication in CIPN through the overload of Ca 2+ entry has been demonstrated (Hill and Oliver, PKC enzyme: Apart from the involvement of PKC on the induction of oxidative stress in neurons, both human and animal studies have linked this enzyme to several pain types through excessive Ca 2+ entry and cation channel activation (Carozzi et al., 2009)

At the same time, it can also cause STAT3 pathway inactivation and PAI-1 activation, leading to severe complications of COVID-19 in some people