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Parkinson's is characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms like tremors, rigidity, and bradykinesia

1 The thyroid gland is small, but mighty

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An increase in total antibodies (including anti-SARS-CoV-2 antibodies) could indicate that the rise in TRAb is part of a generalized immune activation following vaccination

Factors contributing to the suboptimal performance of drugs include the selection of drug targets, the use of biomarkers and animal models in experimental designs, and other issues such as late treatment initiation, dose-dependent side effects, challenges in BBB permeability, and the heterogeneous presentation of patients

Furthermore, its developmental role under different stresses and normal conditions has been recently highlighted (Miura and Tada 2014