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Indeed, glucose 6-phosphate dehydrogenase serves as the major control point for the flux of metabolites through the pentose phosphate pathway

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Unlike OCPs, which suppress the hypothalamicpituitaryovarian (HPO) axis pharmacologically, apigenin and ellagic acid modulate endocrine function physiologically, suggesting potential for safer long-term reproductive outcomes ( 14 Constraints of existing evidence Despite promising preclinical and early clinical findings, several limitations constrain the translation of apigenin and ellagic acid into mainstream PCOS therapy

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