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Down-regulated peroxisome proliferator-activated receptor gamma (PPARgamma) in lung epithelial cells promotes a PPARgamma agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD)

The prescribing physician will decide the appropriate dose and schedule for each individual patient, and patients should strictly follow that advice without alteration

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These may be due to defective DNA synthesis inhibiting replication in a site with a high turnover of cells

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