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238 LyeJ.LatorreE.LeeB.BandinelliS.HolleyJ.GutowskiN.et al (2019)

However, at high doses, silicon becomes toxic, completely inhibiting germination, following the induction of oxidative damage and the progressive inhibition of some hydrolytic and antioxidant enzymes

1.6, p=0.02, bilirubin: 175 vs

It triggers pulsatile GH release without substantially increasing ACTH or cortisol in preclinical work, and has been investigated in human trials for safety in specific clinical settings