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PMID: 21941584

Andree TH Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists

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Further studies revealed that USP22 regulated the ubiquitination and proteasomal degradation of silent information regulator 2-related protein 1 (Sirt1) in GMCs, modulated the AGEs/RAGE pathway, and stimulated the expression of FN and TGF-1, which accelerates the fibrosis process in diabetic kidneys[42]

A cohort study involved 18 patients with Lafora disease, 8 treated with metformin, and 10 untreated showed that metformin was effective in reducing seizure severity and frequency (Burgos et al