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Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

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6.6 Inflammatory cytokines and proteinases During intervertebral disc degeneration (IDD), the formation of an inflammatory microenvironment is a core pathological feature (Zheng et al., 2024), but when the AF is damaged, NP antigens are exposed, activating an autoimmune response, leading to infiltration of immune cells such as macrophages and T lymphocytes, and the release of numerous inflammatory mediators (Wang et al., 2024

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[DOI] [PMC free article] [PubMed] [Google Scholar] [99].Zhang M, He Y, Sun X, Li Q, Wang W, Zhao A, Di W, A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients, J

It is important to recognize that this study focused on transcriptional changes in antioxidant and apoptosis-related genes regulated by Vit A and Lup