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In diet-induced obesity animal models, NNMT inhibition demonstrated metabolic changes including alterations in adipocyte lipid content without affecting food intake patterns, coupled with significant reductions in white adipose tissue mass in treated mice

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Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth

When oxidative stress increases, GSH is consumed to neutralize ROS and is converted into GSSG (oxidized form)

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