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Another possibility is that PDI may be preferentially damaged by the initial peroxide exposure, causing degradation, followed by regeneration from scratch to maintain cellular homeostasis [86]

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Therefore, drugs can be selected on the basis of the expression pattern of ferroptosis-inducing genes (e.g., SLC7A11, GSH, and GPX) or genes associated with metabolic pathways that affect ferroptosis (e.g., GLUT, PDK4, glutaminase, VDAC, and G6PD)

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You can also increase glutathione naturally if you have low levels of it.

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