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Table 1) (Choudhury and Ahmed 2006)

Given both the extent of disability caused by age-related cataract and its costs, $5 to $6 billion per year 26 (Congressional Testimony of S.J

79 Trials eventually restarted when once-daily dosing in dogs showed a lower incidence of CPK elevations

Everolimus pharmacokinetics and its exposuretoxicity relationship in patients with thyroid cancer

Therefore, it is important to investigate i) the impact of CKD on the heart in larger animals and ii) in a more clinically relevant scenario, where other (metabolic) comorbidities, such as DM, co-exist (i.e., the concept of a second hit)