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When it is absent, the entire orchestra can fall out of tune

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The core chelation site relies on the imidazole ring of histidine and the side chain amino group of lysine to ensure the controlled release of copper ions

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The inherent multidrug resistance induced resistance to macrolides and disparities between in vitro drug sensitivity testing and clinical responses all contribute to the complexity of treatment

Treatment with pemetrexed continued until RECIST v1.1 (modified to follow a maximum of 10 target lesions and a maximum of 5 target lesions per organ)-defined progression of disease as determined by the investigator or unacceptable toxicity