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These washout periods, which are highlighted in the Summary of Major Modifications and Explanatory Note, are based on the use of these medications according to the maximum manufacturers licensed doses

When kidney function declines, B12 clearance slows, and serum levels can rise

Beyond Month 6: Maintenance Most patients continue at 2.4 milligrams weekly through month 12, when full clinical trial endpoints are typically reached

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However, commercially available supplements claiming to deliver AOD-9604 often use oral formulations (tablets, capsules, liquids) despite their ineffective bioavailability