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the number of published human cases is small

[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Vasoplegia treatments: the past, the present, and the future

Impaired activity of methionine synthase results in elevated blood concentrations of homocysteine, while impaired activity of L-methylmalonyl-CoA mutase results in increased concentrations of a metabolite of methylmalonyl-CoA called methylmalonic acid (MMA) in blood and urine