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doi: 10.36380/scil.2020.wvj56 11 JangJYKimDImEKimND

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EMBO Mol Med (2013) 5(3):38496

Head Neck 40(4):663-675, 2018

Two signaling mechanisms are involved in the GPx1-dependent regulation of the apoptosis pathway: (1) GPx1 regulates the level of cytosolic H 2 O 2 that oxidizes the redox protein thioredoxin 1, blocking ASK1 activation, and (2) GPx1 interacts with TRAF2 and interferes with the formation of the active ASK1 complex

Ce mcanisme plus doux rduit le risque d'hyperpigmentation rebond, un problme frquent avec les traitements claircissants agressifs, o la pigmentation rapparat, plus fonce encore, aprs l'arrt du traitement