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Its relatively small size and well-characterised binding chemistry make it a practical tool for investigating copper-mediated biological processes in both in vitro and in vivo models

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Evidence for this systems involvement in drug withdrawal derives mostly from opioid studies [46], although there is some evidence of opioid receptor dysfunction in the amygdala in animal models of methamphetamine withdrawal [50] which occurs alongside changes in oxytocin function [50]

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37 The hydroxyphenyl fluorescein (HPF), which is nonfluorescent in original form and emits strong fluorescence in reaction with OH radical, was used to confirm the generation of OH radical