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lysine lactylation (Kla) was elucidated to undergo transfer of lactyl groups from lactyl-CoA

Impaired fatty acid metabolism perpetuates lipotoxicity along the transition to chronic kidney injury

Before making the diagnosis of PFIC, in the paediatric population, other cholestasis disorders should always be considered in the differential diagnosis, including biliary atresia, choledochal malformations, congenital endocrine disorders, inborn errors of metabolism (mainly during the neonatal period) as well as autoimmune liver diseases, drug-induced cholestasis and other genetic diseases in older children [72]

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Yankowski, C., Wirblich, C., Kurup, D

For EtOH-fed mice, the diet contained 2% v/v EtOH (10.8% total calories) in the first wk and the ethanol content increased weekly by 1% until reaching 5% v/v (27% total calorie)