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One major hurdle in drug development is an incomplete understanding of the underlying mechanisms that drive A plaques and tau-containing neurofibrillary tangles (NFTs) in the brain which may begin decades prior to cognitive decline (911)

10.1016/j.ydbio.2010.12.022 194 MuramatsuD.YamaguchiH.MinamisawaY.NiiA

[DOI] [PubMed] [Google Scholar] 20.Maniatis NA, et al

Not surprisingly, inhibition of this cytokine leads to increased risk of cutaneous infection

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Thus, according to patent literature the drug-like 8 and 9 exhibit a very high affinity to the Ang IV binding site named the AT4 receptor