chac1 glutathione CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers Identification of Juglone, a 'first-in-class'

Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv Calcium channel mutants rescue the effect of glutathione depletion. (A) Download Scientific Diagram A scheme of the mechanism of CHAC1 degradation of glutathione enhancing Download Scientific Diagram CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget BACH1CHAC1Glutathione Axis Aggravates Myocardial IschemiaReperfusion Injury by Enhancing Ferroptosis and Oxidative Stress L 2 Hydroxyglutarate sensitizes ferroptosis through ATF3 CHAC1 mediated glutathione degradation in hepatocellular carcinoma Cell Death & Disease

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