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| | 5-Amino-1MQ Monotherapy | None | 50100mg daily | Daily oral or subcutaneous | NNMT inhibition preserves NAD+, activates AMPK and mitochondrial fat oxidation | 812 weeks | Promising preclinical data

Importantly, these symptoms can occur with or without anaemia and/or macrocytosis

The methodology is intended to be applicable to 95% of species (i.e., HC5), particularly for early life stages

We also permitted the use of audio-only communication technology to initiate treatment with buprenorphine in cases where audio-video technology is not available to the beneficiary, provided all other applicable requirements are met

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