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Glia 2012

A.Roma JuniorL

In neurons, lactate is converted into pyruvate by lactate dehydrogenase 1, which then enters the TCA cycle and undergoes oxidative phosphorylation, resulting in the production of significant amounts of ATP to meet the energy demands of normal physiological activities

Glucose metabolism disruptions occur not only in pathology but also with aging, marked by metabolic abnormalities and bioenergetic dysregulation [72]

Although various metalloproteomic approaches, such as IMAC, GE-ICP-MS, biotinylated arsenical pull-down, and fluorescence-based metalloproteomics, have been employed, each method has limitations

Even so, many people fail to get enough of this mineral from their diet, and this is particularly true for elderly individuals and vegetarians