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211 HFD-induced fatty liver may promote liver metastasis by facilitating the secretion of hepatocyte-derived extracellular vesicles (EVs), which transfer Yes-associated protein (YAP) signaling-regulating microRNAs, hence elevating nuclear YAP expression, CYR61 expression, and M2-like macrophage infiltration

The burgeoning field of delivering itaconate via biomimetic carriers to alter intracellular itaconate metabolism may be confronted with great development potential and challenges

Reduced glutathione (the active form) oxidizes rapidly at room temperature a study in the Journal of Pharmaceutical Sciences found 40% potency loss within 14 days at refrigerator temperature and up to 80% loss within 7 days at room temperature

Oral glutathione is generally safe

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The PCR product of all three genes were cloned into blunt end pJET cloning vector (CloneJET TM PCR cloning Kit, Fermentas Life Sciences, USA)