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The activation phase is triggered by a variety of stimuli such as pore-forming bacterial toxins, extracellular ATP, or particulate matter like uric acid crystals, silica, and asbestos

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Another circadian clock protein PER2 inhibits the expression of PAI-1 in a CLOCK/BMAL1-dependent manner as an important factor in the development of these metabolic diseases after the circadian clock system is dysregulated (Oishi et al., 2009)

IFN (in particular IFN-I)-induced metabolic processes may positively and negatively influence the intracellular replication of IBPs, but again, so far little is known on these IFN-mediated metabolic processes and their impact on IBP infections

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