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Subsequently, N-acetyl serotonin is ultimately converted into melatonin by the enzyme known as N-acylserotonin methyltransferase (ASMT) Tryptamine and 5-hydroxytryptophan are metabolized into serotonin through the activity of tryptamine 5-hydroxylase (T5H) and tryptophane decarboxylase (TDC) enzymes, respectively (175, 178, 179)

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Glutamate transport was carried entirely by xCT (Fig

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