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Conventional treatments for joint pain typically focus on symptom management (pain medications, corticosteroid injections) rather than addressing the underlying tissue damage

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As adipose tissue expands, hypoxia and cellular stress trigger adipocyte death and recruit pro-inflammatory M1 macrophages, replacing anti-inflammatory M2 macrophages ( The nuclear factor-kappa B ( NF-B) pathway plays a crucial role in obesity-associated inflammation

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In ATC, Vitamin C induces ferroptosis, which is also associated with ROS [217], further demonstrating the pro-oxidant effect of vitamin C