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The probe drugs can be administered at subtherapeutic doses, as the objective of the study is to observe a pharmacokinetic interaction, rather than a change in pharmacodynamics, in heathy participants

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injecting the drawn volume slowly over 510 seconds

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Kinetics Following an Extravascular Dose OBJECTIVES The reader will be able to: Define the following terms: absorption rate constant, absorption half-life, absorption phase, bioavailability, bioequivalence, biopharmaceutics, delayed-release dosage forms, elimination phase, first-order, flip-flop, generic products, extended-release dosage forms, immediate-release dosage forms, lag time, method of residuals, modified-release dosage forms, peak concentration, peak time, relative bioavailability, zero-order absorption