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GPX synthesis utilizes selenium via selenocysteine and homocysteine is derived from adenosylhomocysteine, and the latter was formed as a result of methylation reactions including methylation of selenium [44]

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These mechanisms avoid the accumulation of damaged/dysfunctional proteins and of protein aggregates, which can reach a toxicity threshold when proteostasis is impaired [34, 35]

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Figure 1 Immunoregulation RA is a common autoimmune disease

Mol Cell 51:6879