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doi: 10.1186/1710-1492-9-46 305

I mean, your reaction is the most common one

MDACC Department of Radiation Oncology - Lecture Series

although its chemical activity is similar to the original drug, MTX-PG 2-6 is preferentially kept in the intracellular environment [whereas non-glutamylated MTX is quickly exported by ABC transporters (8)], and cellular sensitivity to MTX is directly related to the intracellular pool of MTX-PGs (9)

However, in the presence of elevated levels of certain metal ions such as Fe and Cu, SOD can convert hydrogen peroxide to the more hazardous hydroxyl radical (125)