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This point deserves emphasis

PMID: 22463691 | doi:10.1146/annurev-biochem-052110-115718 Mendias CL et al

Hyperalgesic responses in methadone maintenance patients

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We used an regression approach to pre-adjust for peptide, similar to what we did previously for phosphorylation data 81 : where is the abundance level for PTM j for individual i , is the intercept, peptide[ ij ] is the contribution of the corresponding unmodified peptide for PTM j for individual i , and i is the error for individual i , modeled as i N(0, 2 )