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Rupture of the Spleen should be considered in rare cases of chronic hemolytic anemia Chronic Hemolytic Anemia Anemia: Overview and Types

At that point the remaining free radicals and toxins steal electrons from the cells organelles, membranes, and DNA, causing substantial damage and generating even more free radicals

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TOP References Hamel C, Spry C

The key, as with other autoimmune diseases, is to find the root cause of the root cause of the problem