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The depletion can lead to severe neurological complications, megaloblastic anemia , and systemic metabolic dysfunction

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10.1016/j.colsurfb.2017.01.010 12 ChenY.ZhaoG.WangS.HeY.HanS.DuC.et al (2019)

Increased levels of MDA also indicate an upsurge in lipid peroxidation, which may lead to significant alterations in cell membrane function and DNA composition, leading to mutation