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Kong Y, Peng Q, Lv N, Yuan J, Deng Z, Liang X, et al

Higher baseline opioid dose was the strongest and most consistent predictor of opioid-involved overdose or opioid overdose-related death

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123,124 Astrocytes are estrogen targets, 125 as both ER1 and ER2 receptors are present on the astrocyte membrane or intracellularly in astrocytes

Works great too for sore joints and muscles