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PGC1A is a transcriptional coactivator that plays a central role in the expression of genes acting against oxidative stress in combination with FOXO3A 29

In a recent 12-week, randomized, placebo-controlled trial in untreated hypertensive subjects, daily intake of aged garlic extract (1.2 g of which contained 1.2 mg of S-allyl-L-cysteine [SAC]) was shown to significantly lower SBP by 11 mm Hg and DBP by 6 mm Hg on average in 50%-60% of participants, but reductions in blood pressure were not reported in 40%-50% of participants compared to placebo (110)

Omega-3 fatty acids, found in certain fish and fish oil capsules, are good fats that help these receptors function properly

"There have also been many other side effects reported, such as nausea, vomiting, headaches, kidney failure, and you can also get brain swelling," Dr Yip said

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