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Methimazole, an oral antithyroid medication which is a potent peroxidase and tyrosinase inhibitor, has shown depigmentation effects when applied topically and caused significant skin lightening in patients with melasma [75, 78, 96, 97]

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Scientific References: Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F Jr, Olson EN, Srivastava D., International Immunopharmacology , 2023