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Middelburg et al

Moreover, mechanistic studies show that bronchoconstriction in ASMC causes mechanical stress on the airway epithelium, triggering the release of epithelial growth factors like TGF- and EGF, which leads to airway remodeling in asthma, as illustrated in Figure 11 (109, 112)

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o indicates a remarkable decrease in edema, oxidative stress, and hemorrhage

In atherosclerotic plaque, increased matrix metalloproteinase expression and activity triggered by oxidative stress lead to its rupture and consequent thrombosis (He and Zuo, 2015)

IV NAD+ may benefit patients weaning off opioid, alcohol, chemical, or prescription drug dependencies