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In summary, we speculated that M1 polarization results in increased oxidative stress, but M2 polarization impairs antioxidant capacity

Dearsly, A.L., Nicholas, J

Neuropsychopharmacology (2026)

They inhibit pro-inflammatory cytokines and reduce ROS levels in macrophages near the affected peripheral nerves

This is usually temporary and settles within a few days

Sci Rep 10:2214 Mertens LJ, Wall MB, Roseman L, Demetriou L, Nutt DJ, Carhart-Harris RL (2020) Therapeutic mechanisms of psilocybin: changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant dePression