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In addition, suppressor of cytokine signal transduction protein 1 (SOCS1) is required for p53 activation and regulates the expression of p53 target gene for cellular senescence

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In the per-protocol population, the median [mean] annualized bleed rate (ABR) in the on-demand treatment arm was 41.5 [40.8] compared to 1.9 [3.7] while on a twice a week prophylaxis regimen

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doi: 10.1111/j.1742-4658.2008.06515.x 250 WoloskerH.RadzishevskyI

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