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Acknowledgments This research was supported by a Grant-in-Aid for Exploratory Research (grant number 16K20081) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, Tokyo, Japan

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Structurally, Dihexa is derived from angiotensin IV a naturally occurring peptide involved in brain function but has been chemically modified to dramatically enhance its potency and its ability to penetrate the blood-brain barrier

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